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Non-invasively measured biomarkers of Alzheimer’s disease – Simon-Shlomo Poil

Our daily life is based on being able to remember information over long intervals of time. This week we publish an article in PNAS, which shows a possible link between abnormal brainwaves in patients with Alzheimer’s disease and a decline in cognitive function.

Click here for the abstract of this article and more information

We measured the brainwaves of patients with Alzheimer’s disease and healthy subjects using a non-invasive method called magnetoencephalography (MEG – a method almost similar to electroencephalography (EEG)) . We found that the brainwaves in patients with Alzheimer’s disease were less stable and had weaker correlations over time compared to healthy subjects.

Our results shows that (1) non-invasively measured biomarkers of abnormal brainwave can identify certain aspects of Alzheimer’s disease, and (2) brainwaves might give us a better understanding of Alzheimer’s disease and brain function in general.

Our article has been released in PNAS early edition click here to see article. Please contact my supervisor Klaus Linkenkaer-Hansen for more information.

(Montez & Poil et al., Altered temporal correlations in parietal alpha and prefrontal theta oscillations in early-stage Alzheimer disease, PNAS early edition 21.01.2009)

This article has also been described at the Alzheimer Reseach forum webpage


Non-invasively measured biomarkers of Alzheimer’s disease